Community & Caregiver Support

Additional CML Resources for You and Caregivers

If you are looking for additional support or information, you can find external programs and networks below. Visit their websites or call directly with the phone numbers provided.

Cancer Support Community™

The Cancer Support Community is an international nonprofit dedicated to providing support, education, and hope to people affected by cancer.

Phone: 1-888-793-9355

Caregiver Action Network

The Caregiver Action Network provides education, peer support, and resources to family caregivers across the United States, free of charge.

Phone: 1-202-454-3970

Leukemia & Lymphoma Society (LLS)

An organization on the front lines of the fight to cure blood cancer. LLS is dedicated to research, patient access, and policy and advocacy. It has resources available for both patients and caregivers to help them in their journey with Ph+ CML.

Phone: 1-800-955-4572

Well Spouse^® Association

The Well Spouse Association advocates for and addresses the needs of individuals caring for a chronically ill and/or disabled spouse/partner.

Phone: 1-732-577-8899

Learn More About CML

American Cancer Society^®

Phone: 1-800-227-2345

The National CML Society

CancerCare^®

Phone: 1-800-813-4673

For Caregivers: Helping Your Loved One Throughout Their Journey

When a loved one has Ph+ CML, there are many things you can do to help them through their disease and treatment. Use the information in this brochure to help them with:

Understanding their disease and treatment
Creating a routine with BOSULIF
Managing potential side effects

You can make a difference in your loved one’s treatment

Reminders about treatment, emotional support, and accompanying your loved one when talking to healthcare professionals (HCPs) can help make your loved one’s journey with BOSULIF easier.

Use the following reminders to help your loved ones:

Review the tips for managing side effects so you know how to help them cope

Help them reach out to their doctor or HCP if they have questions or concerns

Record appointments and testing dates and remind them as they approach

Remind them to take their treatment at the same time every day

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IMPORTANT SAFETY INFORMATION AND INDICATIONS FOR PATIENTS

Do not take BOSULIF if you are allergic to bosutinib or any of the ingredients in BOSULIF.

Before you take BOSULIF, tell your doctor if you:

have liver problems
have heart problems
have kidney problems
have high blood pressure
have diabetes
are pregnant or plan to become pregnant. BOSULIF can harm your unborn baby. Tell your doctor right away if you become pregnant while taking BOSULIF
- Females who are able to become pregnant should have a pregnancy test before starting treatment with BOSULIF and should use effective birth control (contraception) during treatment with BOSULIF and for at least 2 weeks after the last dose. Talk to your doctor about birth control methods that may be right for you
are breastfeeding or plan to breastfeed. It is not known if BOSULIF passes into your breast milk or if it can harm your baby. Do not breastfeed during treatment with BOSULIF and for at least 2 weeks after the last dose

Tell your doctor about the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. BOSULIF and certain other medicines can affect each other.

BOSULIF may cause serious side effects, including:

Stomach problems. BOSULIF may cause stomach (abdomen) pain, nausea, diarrhea, vomiting, or blood in your stools. Get medical help right away for any stomach problems
Low blood cell counts. BOSULIF may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). Your doctor should do blood tests to check your blood cell counts regularly during your treatment with BOSULIF. Call your doctor right away if you have unexpected bleeding or bruising, blood in your urine or stools, fever, or any signs of an infection
Liver problems. Your doctor should do blood tests to check your liver function regularly during your treatment with BOSULIF. Call your doctor right away if your skin or the white part of your eyes turns yellow (jaundice), or you have dark “tea color” urine
Heart problems. BOSULIF may cause heart problems, including heart failure and decreased blood flow to the heart, which can lead to heart attack. Get medical help right away if you get shortness of breath, weight gain, chest pain, or swelling in your hands, ankles, or feet
Your body may hold too much fluid (fluid retention). Fluid may build up in the lining of your lungs, the sac around your heart, or your stomach cavity. Get medical help right away if you get any of the following symptoms during your treatment with BOSULIF:

shortness of breath and cough
chest pain
swelling in your hands, ankles, or feet
swelling all over your body
weight gain

Kidney problems. Your doctor should do tests to check your kidney function when you start treatment with BOSULIF and during your treatment. Call your doctor right away if you get any of the following symptoms during your treatment with BOSULIF:

you urinate more or less often than normal
you make a much larger or smaller amount of urine than normal

The most common side effects of BOSULIF in adults and children with CML include diarrhea, stomach (abdominal) pain, vomiting, nausea, rash, tiredness, liver problems, headache, fever, decreased appetite, respiratory tract infections (infections in nose, throat, or lungs), constipation, and changes in certain blood tests. Your doctor may do blood tests during treatment with BOSULIF to check for changes.

Tell your doctor or get medical help right away if you get respiratory tract infections, loss of appetite, headache, dizziness, back pain, joint pain, rash, or itching while taking BOSULIF. These may be symptoms of a severe allergic reaction.

Your doctor may change your dose, temporarily stop, or permanently stop treatment with BOSULIF if you have certain side effects.

BOSULIF may cause fertility problems in both female and male patients. This may affect your ability to have a child. Talk to your doctor if this is a concern for you.

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of BOSULIF. For more information, ask your doctor or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.

INDICATIONS

BOSULIF is a prescription medicine used to treat:

adults and children 1 year of age and older who have a certain type of leukemia called chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML) who are newly diagnosed or who no longer benefit from or did not tolerate other treatment
adults with accelerated phase (AP) or blast phase (BP) Ph+ CML who can no longer benefit from or did not tolerate other treatment

It is not known if BOSULIF is safe and effective in children less than 1 year of age with CP Ph+ CML who are newly diagnosed or who no longer benefit from or did not tolerate other treatment or in children with AP Ph+ CML or BP Ph+ CML.

Please see Patient Information and full Prescribing Information.

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